Prooxidant Mechanisms in Iron Overload Cardiomyopathy
نویسندگان
چکیده
منابع مشابه
Prooxidant Mechanisms in Iron Overload Cardiomyopathy
Iron overload cardiomyopathy (IOC), defined as the presence of systolic or diastolic cardiac dysfunction secondary to increased deposition of iron, is emerging as an important cause of heart failure due to the increased incidence of this disorder seen in thalassemic patients and in patients of primary hemochromatosis. At present, although palliative treatment by regular iron chelation was recom...
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Oxidative stress is an important aspect of toxicology and therefore of considerable interest. It can be traced back to 1954 when Gerschman et al. propounded the free radical theory which for the first time implicated partially reduced forms of oxygen in its toxic mechanism [1]. This was followed by Harman in 1956 proposing the concept of free radicals playing a role in the ageing process [2]. T...
متن کاملHydrophilic Phytochelators in Iron Overload Condition
Background: Iron overload can cause many complications and damage many organs as well as physiologic functions. Consumption of phetochemicals and flavonoids with iron chelating ability, instead of synthetic iron chelators, can be less harmful and more effective. The aim of this review is to investigate hydrophilic phytochelators in iron overload condition. Methods: In this review, the possible ...
متن کاملAn autopsy case of secondary iron-overload cardiomyopathy.
A woman over 70 years of age presented with anemia and appetite loss. She had no history of blood transfusions, although she had been receiving iron infusions for anemia for seven years. She had an elevated serum ferritin level (7,951 ng/mL) one month before admission. Abdominal computed tomography showed increased hepatic density and echocardiography showed normal heart valves and heart-wall m...
متن کاملEndocrine Dysfunctions in Iron Overload in Patients with Major Thalassemia
Abstract Background The aim of the present study was to determine the endocrine dysfunction in patients with major thalassemia, who receive hyper transfusion. Materials and Methods This cross sectional study was performed during one year, which included 65 major thalassemia patients (31 females and 34 males), aged between 14 month to 27 years old (median 10,3). Growth assessment was measur...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2013
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2013/740573